Research Fellowship

Protection of pigs against Taenia solium cysticercosis by immunization with novel recombinant antigens

CG Gauci, CM Jayashi, AE Gonzalez, J Lackenby, MW Lightowlers

2012-06-06

Recombinant antigens from the oncosphere stage of the parasite Taenia solium were expressed in Escherichia coli. The TSOL16, TSOL4..

Strategies for optimal expression of vaccine antigens from taeniid cestode parasites in escherichia coli

C Gauci, D Jenkins, MW Lightowlers

2011-07-01

Investigations were undertaken into optimizing the expression of Cestode parasite vaccine antigens in the bacterium, Escherichia c..

Comparative Pathology of Pulmonary Hydatid Cysts in Macropods and Sheep

TS Barnes, LA Hinds, DJ Jenkins, H Bielefeldt-Ohmann, MW Lightowlers, GT Coleman

2011-02-01

The development and appearance of hydatid cysts of Echinococcus granulosus in experimentally infected tammar wallabies (Macropus e..

Oncospheral penetration glands are the source of the EG95 vaccine antigen against cystic hydatid disease

A Jabbar, DJ Jenkins, S Crawford, AK Walduck, CG Gauci, MW Lightowlers

2011-01-01

Immunohistochemistry and immunogold labelling techniques were used to localize the EG95 vaccine antigen in Echinococcus granulosus..

Vaccines to combat the neglected tropical diseases

JM Bethony, RN Cole, X Guo, S Kamhawi, MW Lightowlers, A Loukas, W Petri, S Reed, JG Valenzuela, PJ Hotez

2011-01-01

Summary: The neglected tropical diseases (NTDs) represent a group of parasitic and related infectious diseases such as amebiasis, ..

Fact or hypothesis: Taenia crassiceps as a model for Taenia solium, and the S3Pvac vaccine

MW Lightowlers

2010-11-01

Research undertaken over the past 40-years has established many of the general principals concerning immunity to taeniid cestodes...

Oncospheral penetration glands and secretory blebs are the sources of Taenia ovis vaccine antigens

A Jabbar, S Crawford, CG Gauci, AK Walduck, GA Anderson, MW Lightowlers

2010-10-01

Taenia ovis is a cestode parasite infecting primarily sheep as intermediate hosts and dogs as definitive hosts. The first highly e..

Ultrastructural reconstruction of Taenia ovis oncospheres from serial sections

A Jabbar, S Crawford, D Młocicki, ZP Świderski, DB Conn, MK Jones, I Beveridge, MW Lightowlers

2010-10-01

The cellular organisation of Taenia ovis oncospheres is interpreted from ultrathin serial sections and transmission electron micro..

Variation in the cellular localization of host-protective oncospheral antigens in Taenia saginata and Taenia solium

A Jabbar, M Verástegui, JA Lackenby, AK Walduck, CG Gauci, RH Gilman, MW Lightowlers

2010-09-01

Immunohistochemistry and immunofluorescence with confocal microscopy were used to localize the host-protective antigens of Taenia ..

Eradication of Taenia solium cysticercosis: A role for vaccination of pigs

MW Lightowlers

2010-08-01

Taenia solium is the causative agent of neurocysticercosis, a disease responsible for substantial human morbidity and mortality. I..

Fact or hypothesis: Concomitant immunity in taeniid cestode infections

MW Lightowlers

2010-08-01

Sustained research efforts over the last 50 years have revealed a considerable amount of information about immunity to taeniid ces..

Antibody responses to the host-protective Taenia solium oncosphere protein TSOL18 in pigs are directed against conformational epitopes

E Assana, CG Gauci, CT Kyngdon, AP Zoli, P Dorny, S Geerts, MW Lightowlers

2010-06-01

TSOL18 is a recombinant protein that has been shown in repeated experimental trials to be capable of protecting pigs against chall..

Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon

E Assana, CT Kyngdon, CG Gauci, S Geerts, P Dorny, R De Deken, GA Anderson, AP Zoli, MW Lightowlers

2010-04-01

A pilot field trial of the TSOL18 vaccine was undertaken in Cameroon. Two hundred and forty, 2-3. month-old piglets were distribut..